Sermorelin
GHRH 1-29. The bioidentical first-line growth-hormone secretagogue.
- Raises your own growth hormone and IGF-1, naturally.
- Supports recovery and better sleep.
- A favorite for healthy-aging protocols.
- Long, well-established safety track record.
Truncated 29-amino-acid GHRH fragment. Stimulates the pituitary on the same pathway as native GHRH with a controlled half-life.
Sermorelin is GHRH(1-29), the shortest fully active fragment of native growth-hormone-releasing hormone. Pulsatile GH release rather than sustained signal — preferred when HPA-axis preservation matters.
- 1200–500 mcg subcutaneous, once daily before sleep.
- 2Cycle: 12 weeks on, 4 weeks off.
- Reconstitution
- 1 mL bacteriostatic water into a 5 mg vial → 5 mg/mL (each 0.04–0.06 mL = 200–300 mcg).
- Typical research dose
- Reference 200–300 mcg per administration.
- Frequency
- Once daily before sleep, subcutaneous.
- Vial duration
- A 5 mg vial covers ~16 nights at 300 mcg and ~25 nights at 200 mcg — both inside the 30-day reconstituted-use window.
- Storage
- Refrigerate 2–8 °C; use within 30 days reconstituted.
Understanding Sermorelin
A gentle way to raise your own growth hormone
Written for people new to peptides. Clear language, careful claims, no dosing instructions.
+What is Sermorelin?
Sermorelin is the first 29 amino acids of natural GHRH — the active part of the molecule. It is one of the original GHRH-class peptides and is often used as a milder, more 'physiological' entry point to supporting GH.
Because it is short-acting, it produces a brief, clean GH pulse rather than a sustained elevation — which is why it is so commonly chosen for bedtime dosing aligned with the body's natural overnight GH pulse.
+How Sermorelin was discovered
Sermorelin was synthesized in the 1970s by Roger Guillemin's group (a line of work that won the 1977 Nobel Prize) as the shortest active fragment of GHRH. It was approved by the FDA in 1997 as Geref for pediatric GH deficiency.
After the brand was withdrawn for commercial reasons, sermorelin moved into compounded and research use, where it has been one of the most widely prescribed GH-related peptides for two decades.
+How Sermorelin works in the body
- Sermorelin binds GHRH receptors in the anterior pituitary and triggers release of stored growth hormone.
- The resulting GH pulse stimulates hepatic IGF-1 production, which mediates downstream effects on lean tissue, recovery, and metabolism.
- Because it does not bind ghrelin receptors, it doesn't raise cortisol, prolactin, or appetite the way older GHRPs do.
+Benefits
- Raises your own growth hormone and IGF-1, naturally.
- Supports recovery and better sleep.
- A favorite for healthy-aging protocols.
- Long, well-established safety track record.
+Research highlights
Sermorelin has a long clinical history, including pediatric GH-deficiency trials in the 1990s, and remains widely studied as a tool to support the body's own GH output without above-normal peaks.
It is often used as the 'control' GHRH in protocols comparing newer molecules like tesamorelin or CJC-1295.
Research interest extends to age-related GH decline (somatopause), sleep quality, and body-composition endpoints in adults.
+What researchers commonly report
Improved sleep, gradual recovery improvements, and steady but subtle body-composition shifts are typical anecdotal reports — usually described as 'milder than CJC/Ipamorelin' but cleaner.
+Why researchers find Sermorelin interesting
Sermorelin is the original GHRH-class molecule and remains the reference point for everything that came after. Its short, clean pulse is the closest match to the body's own GHRH signal of any peptide in the catalog.
+Quality markers we look for
- HPLC purity reviewed with a target of ≥99%
- Mass spectrometry identity confirmation
- LAL endotoxin screening on applicable batches
- Lyophilized (freeze-dried) format for stability
- Careful storage and handling — keep cold, reconstitute with sterile water
+Often paired with
The data your lab notebook needs.
Pulled from the verification packet included with each shipment. Cross-check the batch ID on your vial against the COA.
- Molecular Weight
- 3357.93 g/mol
- Sequence Length
- 29 amino acids
- CAS Number
- 86168-78-7
- Synonyms
- GRF 1-29, Geref
- Purity
- 99%+
- Source
- Synthetic
- Storage
- Lyophilized: 2–8 °C. Reconstituted: 2–8 °C, use within 30 days.
- Reconstitution
- Add 2 mL bacteriostatic water. Each 0.2 mL = 500 mcg.
- Half-life
- ~10–20 minutes