Selank
Russian nootropic heptapeptide. Anxiolytic without sedation.
- Delivers a calm, focused mental state.
- Eases anxiety.
- Improves sleep and stress resilience.
- No drowsiness, unlike typical anti-anxiety options.
Synthetic analog of tuftsin. Anxiolytic effects with no withdrawal profile; BDNF upregulation in hippocampus.
Selank is a synthetic tuftsin analog with proline-rich C-terminal stabilization. Russian clinical work describes anxiolytic effects comparable to short-acting benzodiazepines without sedation.
- 10.5 mg subcutaneous, once daily, 5 days per week (2 days off).
- Reconstitution
- 2 mL bacteriostatic water into a 10 mg vial → 5 mg/mL (each 0.1 mL = 500 mcg).
- Typical research dose
- Commonly referenced at 0.5 mg per administration, subcutaneous.
- Frequency
- Once daily, 5 days per week (2 days off).
- Vial duration
- A 10 mg vial covers ~4 weeks at 0.5 mg/day on a 5-day-per-week schedule (≈2.5 mg per week, 20 dosing days) — inside the 30-day reconstituted-use window.
- Storage
- Refrigerate 2–8 °C; use within 30 days reconstituted.
- Rotate subcutaneous injection sites to minimize local irritation.
Understanding Selank
Calm focus, without the drowsiness
Written for people new to peptides. Clear language, careful claims, no dosing instructions.
+What is Selank?
Selank is a short peptide modeled on tuftsin, a natural fragment that helps balance immune activity. It was developed alongside Semax in Russia and is used there for generalized anxiety research.
It is the most-discussed peptide in the anti-anxiety and stress-resilience corner of nootropic research.
+How Selank was discovered
Selank was developed in the 1990s at the same Russian Institute of Molecular Genetics that produced Semax. It is a synthetic analogue of tuftsin, a natural peptide fragment that helps balance immune activity.
It was approved in Russia and is used clinically there for generalized anxiety disorder. Its non-sedating profile is what made it stand out from classical benzodiazepine-class anxiolytics.
+How Selank works in the body
- Selank adjusts GABA-receptor activity — the brain's main calming system — without the sedation, dependence or memory issues of classic anxiolytics.
- It also influences enkephalin levels (the body's natural calming opioids) and BDNF activity, which is part of why mood and cognitive endurance effects are described alongside its anxiolytic profile.
- It has documented effects on balancing the immune system via the tuftsin pathway, which is why some research framing includes a 'stress-immune' connection.
+Benefits
- Delivers a calm, focused mental state.
- Eases anxiety.
- Improves sleep and stress resilience.
- No drowsiness, unlike typical anti-anxiety options.
+Research highlights
Selank has Russian clinical data in generalized anxiety disorder and adjustment disorder, with head-to-head comparisons against benzodiazepines showing comparable anxiolysis without sedation. Western controlled trials are limited.
Main research areas: GABA-system effects, enkephalin biology, anxiety/PTSD models, and stress-immune crosstalk.
Compared with Semax it sits at the calming end of the same Russian peptide family — they are designed to be complementary.
+What researchers commonly report
A quieter, more even baseline mental state — without sedation — is the most common report. Improvements in sleep are also frequently noted.
+Why researchers find Selank interesting
Selank is interesting as a non-sedating anxiolytic peptide — a combination that is essentially unique in the catalog. Most anti-anxiety molecules trade alertness for calm; Selank's research profile claims it doesn't have to.
+Quality markers we look for
- HPLC purity reviewed with a target of ≥99%
- Mass spectrometry identity confirmation
- LAL endotoxin screening on applicable batches
- Lyophilized (freeze-dried) format for stability
- Careful storage and handling — keep cold, reconstitute with sterile water
+Often paired with
The data your lab notebook needs.
Pulled from the verification packet included with each shipment. Cross-check the batch ID on your vial against the COA.
- Molecular Weight
- 751.86 g/mol
- Sequence
- Thr-Lys-Pro-Arg-Pro-Gly-Pro (7 AA)
- CAS Number
- 129954-34-3
- Synonyms
- TP-7 analog
- Purity
- 99%+
- Source
- Synthetic
- Storage
- Lyophilized: 2–8 °C. Reconstituted: 2–8 °C, use within 30 days.
- Reconstitution
- Add 2 mL bacteriostatic water for nasal solution. Each 0.1 mL spray = 550 mcg.
- Half-life
- ~15 minutes (CNS effects longer)