CJC-1295 / Ipamorelin
Pre-blended GHRH + GHRP. The cleanest endogenous GH pulse.
- Boosts natural growth hormone and IGF-1 output.
- Supports lean muscle and faster recovery between workouts.
- Deepens sleep.
- Supports skin, hair, and connective tissue over time.
Pre-blended CJC-1295 (no DAC) and Ipamorelin. CJC drives the GHRH side; ipamorelin selectively triggers the ghrelin receptor without cortisol spillover.
The standard research blend for IGF-1 elevation without endocrine side effects. CJC-1295 no DAC is a tetrasubstituted GHRH analog with a ~30 minute half-life; ipamorelin is the most selective GHRP available, with no measurable rise in ACTH, cortisol, or prolactin.
- 1100 mcg + 100 mcg subcutaneous, fasted, 1–3× daily.
- 2Pre-sleep dose commonly emphasized to preserve nocturnal GH pulse.
- 3Cycle: 12 weeks on, 4 weeks off.
- Reconstitution
- 2 mL bacteriostatic water into the 10 mg blended vial → 5 mg/mL combined (each 0.1 mL ≈ 250 mcg of each peptide, i.e. 500 mcg total).
- Typical research dose
- Reference ~250 mcg of each peptide per administration (500 mcg total per dose).
- Frequency
- 1–2× daily, subcutaneous, fasted state — pre-sleep dose commonly emphasized.
- Vial duration
- A 10 mg blended vial covers ~20 days at 1 administration/day and ~10 days at 2 administrations/day — both inside the 30-day reconstituted-use window.
- Storage
- Refrigerate 2–8 °C; use within 30 days reconstituted.
- GHRH + GHRP stack — fasted 1–2 hr window often referenced to preserve GH-pulse amplitude.
Understanding CJC-1295 / Ipamorelin
The go-to growth hormone stack
Written for people new to peptides. Clear language, careful claims, no dosing instructions.
+What is CJC-1295 / Ipamorelin?
This blend pairs two peptides that work on different parts of the same growth-hormone signaling chain. CJC-1295 is a stabilized GHRH analogue; Ipamorelin acts selectively on the ghrelin receptor (a GHRP).
Run together they produce a larger and more natural GH pulse than either peptide alone, while preserving the body's own pulsatile rhythm — which is the main reason researchers favor the stack over recombinant HGH.
Most blends sold today are CJC-1295 'without DAC' — i.e. without the albumin-binding tail — which keeps the GH pulse short and clean instead of producing a sustained plateau.
+How CJC-1295 / Ipamorelin was discovered
CJC-1295 was developed at ConjuChem in the mid-2000s as a long-acting GHRH analogue. Ipamorelin was developed at Novo Nordisk in the late 1990s as a compound that acts very selectively on the ghrelin receptor. The two were never originally marketed together — the blend became a research-community standard because the mechanisms are so complementary.
The combination is now one of the most widely referenced GH-secretagogue stacks in performance and longevity research.
+How CJC-1295 / Ipamorelin works in the body
- CJC-1295 binds GHRH receptors on the pituitary and amplifies the size of each natural GH pulse.
- Ipamorelin binds the ghrelin/GHS receptor and adds an independent push on GH release while suppressing somatostatin — the brake that normally limits how much GH is released.
- Ipamorelin is notable for being highly selective: unlike older GHRPs (GHRP-6, GHRP-2), it does not meaningfully raise cortisol or prolactin, which is part of why it has displaced older GHRPs in research protocols.
+Benefits
- Boosts natural growth hormone and IGF-1 output.
- Supports lean muscle and faster recovery between workouts.
- Deepens sleep.
- Supports skin, hair, and connective tissue over time.
+Research highlights
Both peptides have been studied individually in clinical and research settings — CJC-1295 in dose-finding pharmacology trials, ipamorelin across multiple Phase 2 trials for postoperative ileus.
The combination is widely discussed in performance and longevity research as a way to support GH levels while keeping the natural pulse pattern intact — particularly the deep-sleep GH pulse.
Compared with tesamorelin (GHRH alone) the stack adds a second 'push' on the pituitary, which is why research models often show a larger GH AUC than GHRH-only molecules.
+What researchers commonly report
Deeper sleep, faster recovery between hard sessions, and gradual body-composition changes over months are the most common anecdotal reports. Some researchers describe a transient 'flushing' sensation from the ipamorelin arm in the first minutes after dosing.
+Why researchers find CJC-1295 / Ipamorelin interesting
The CJC-1295 / Ipamorelin stack is interesting because it gets meaningful GH support out of the body's own pituitary instead of replacing the hormone from outside — preserving the natural GH pulse profile that HGH from outside the body flattens.
+Quality markers we look for
- HPLC purity reviewed with a target of ≥99%
- Mass spectrometry identity confirmation
- LAL endotoxin screening on applicable batches
- Lyophilized (freeze-dried) format for stability
- Careful storage and handling — keep cold, reconstitute with sterile water
+Often paired with
The data your lab notebook needs.
Pulled from the verification packet included with each shipment. Cross-check the batch ID on your vial against the COA.
- Composition
- 5 mg CJC-1295 no DAC + 5 mg Ipamorelin
- CJC-1295 (no DAC)
- MW 3367.85 g/mol · 29 AA · CAS 863288-34-0
- Ipamorelin
- MW 711.85 g/mol · 5 AA · CAS 170851-70-4
- Purity
- 99%+ HPLC
- Purity
- 99%+
- Source
- Synthetic blend
- Storage
- Lyophilized: 2–8 °C. Reconstituted: 2–8 °C, use within 30 days.
- Reconstitution
- Add 2 mL bacteriostatic water to the 10 mg blend. Each 0.02 mL = 100/100 mcg.
- Half-life
- CJC ~30 min; Ipamorelin ~2 hours